A High-fat Diet Alters the Phenotype of Diabetic Neuropathy By
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چکیده
iii Acknowledgements v List of Figures xiii Chapter One: Introduction 1 1. Diabetes Mellitus 2 2. Diabetic Neuropathy 3 3. Dyslipidemia and Lifestyle Factors 6 4. Mitochondrial Dysfunction 12 5. Inflammation 15 6. Peripheral Nervous System Insulin Resistance 19 7. Exercise Intervention as a Preventative and Treatment for Diabetic Neuropathy 21 8. Study Significance 24 Chapter Two: Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl/6 Mice 27 1. Abstract 28 2. Introduction 29 3. Experimental Procedures 30 4. Results and Figures 35 5. Discussion 44
منابع مشابه
Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl/6 Mice
Emerging evidence suggests that dyslipidemia is an independent risk factor for diabetic neuropathy (DN) (reviewed by Vincent et al. 2009). To experimentally determine how dyslipidemia alters DN, we quantified neuropathic symptoms in diabetic mice fed a high-fat diet. Streptozotocin-induced diabetic C57BL/6 mice fed a high-fat diet developed dyslipidemia and a painful neuropathy (mechanical allo...
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